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在DCIS进展中的表观遗传变化:IncRNAs可以教我们什么?

Igor Petrone^1,2, Everton Cruz Dos Santos^1,2, Renata Binato^1,2

¹Stem Cell Laboratory, Center for Bone Marrow Transplants, Brazilian National Cancer Institute-INCA, Rio de Janeiro 20230-240, Brazil.

International journal of molecular sciences

|May 27, 2023

概括

长非编码RNAs (lncRNAs) 在乳腺癌 (BC) 的发展中发挥作用. 了解管道癌 in situ (DCIS) 中的 lncRNA 调节是预测其进展到侵袭性BC的关键.

科学领域:

分子生物学分子生物学
基因组学就是基因组学.
癌症研究癌症研究

背景情况:

哺乳动物基因组编码未转化为蛋白质的转录,包括长非编码RNA (lncRNAs).
lncRNAs作为诱,支架和增强器RNA的功能,调节像microRNAs这样的分子.
异常的lncRNA表达与乳腺癌 (BC) 的发病和进展有关.

研究的目的:

审查目前关于lncRNAs在管道癌 in situ (DCIS) 中的作用的知识.
探索 lncRNAs 对DCIS向侵袭性BC.进展的潜在贡献.
突出确定DCIS侵袭性BC进展的预测生物标志物的重要性.

主要方法:

关于lncRNAs和乳腺癌的研究的文献综述.
对癌症中 lncRNAs 的调节机制的分析.
检查与BC进展中的lncRNAs相关的遗传和表观遗传变化.

主要成果:

lncRNAs参与了各种生物学途径,这些途径对癌症至关重要.
改变的lncRNA表达与BC启动和进展有关.
lncRNAs可能在从非侵入性DCIS过渡到侵入性BC的过程中发挥作用.

结论:

更深入地了解 lncRNA 调节机制是必不可少的.
在BC病原和进展中,lncRNAs具有重要意义.
鉴定lncRNA生物标志物可以帮助预测DCIS进展,改善患者的治疗结果.

关键词:

在DCIS的进展过程中,DCIS的进展.乳腺癌乳腺癌乳腺癌这是表观遗传学.长非编码RNAs的编码.

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