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受伤的内皮细胞:肺纤维化的一个危险因素
Weiming Zhao1, Lan Wang1, Yaxuan Wang1
1State Key Laboratory of Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Organ Fibrosis, Institute of Biomedical Science, College of Life Science, Henan Normal University, Xinxiang 453007, China.
International journal of molecular sciences
|May 27, 2023
概括
内皮细胞通过内皮-介质细胞过渡 (E(nd) MT) 转化为肌纤维细胞,从而导致肺纤维化 (PF). 这一过程推动了纤维细胞积累和细胞外基质沉积在纤维化肺组织中.
科学领域:
- 肺部医学 肺部医学
- 细胞生物学 细胞生物学
- 病变发生研究研究 病变发生研究
背景情况:
- 肺纤维化 (PF) 的特征是肌纤维细胞激活和细胞外基质 (ECM) 沉积.
- 对于PF的确切病原性仍然不完全理解.
- 内皮细胞越来越多地被认为在PF发育中的重要作用.
研究的目的:
- 检查肺纤维化中内皮-介质细胞转换 (E(nd) MT) 的作用.
- 探索内皮细胞如何促进纤维细胞增殖和ECM积累.
- 提供有关纤维细胞起源和PF的激活机制的见解.
主要方法:
- 文献综述侧重于内皮细胞和肺纤维化.
- 对调查内皮细胞分化成介质细胞的研究进行分析.
- 检查由内皮细胞衍生的细胞对纤维化过程的贡献.
主要成果:
- 内皮细胞可以通过E(nd) MT.转化为介质细胞.
- 纤维化小鼠肺中的约16%的纤维细胞来自内皮细胞.
- E(nd) MT导致内皮衍生的间细胞过度增殖,导致PF病理.
结论:
- 内皮细胞在肺纤维化病原发生过程中起着至关重要的作用.
- 乙是驱动纤维细胞积累和PF中的ECM沉积的关键机制.
- 了解E(nd) MT为研究PF和潜在的治疗标提供了新的途径.
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