功能失调的自,蛋白质稳定和线粒体作为与年龄相关的黄斑退化症的序幕
Raji Rajesh Lenin1,2, Yi Hui Koh1, Zheting Zhang1,3
1Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228, Singapore.
International journal of molecular sciences
|May 27, 2023
概括
线粒体功能障碍和自功能障碍有助于与年龄相关的黄斑变性 (AMD). 针对这些过程显示出新的AMD治疗方法的希望.
科学领域:
- 眼科医生 眼科 眼科
- 细胞生物学 细胞生物学
- 老年学是一门学科.
背景情况:
- 视网膜色素上皮 (RPE) 细胞功能障碍是与年龄相关的黄斑变性 (AMD) 的核心.
- 在RPE细胞中,氧化应激导致细胞损伤的积累,特别是线粒体功能障碍.
- 线粒体功能障碍越来越多地与衰老和AMD病变产生有关,影响视力丧失.
研究的目的:
- 审查在干燥的AMD中将自,蛋白质稳定和线粒体功能障碍联系在一起的证据.
- 讨论用于研究AMD中的线粒体功能障碍以及药物查的体外和体内模型.
- 总结正在进行的针对线粒体功能障碍的临床试验,用于AMD治疗.
主要方法:
- 关于干燥AMD中自,蛋白质稳定和线粒体功能障碍的当前证据的文献综述.
- 对AMD研究现有的体外和体外模型的分析.
- 对正在进行的临床试验的调查,重点是AMD治疗中线粒体功能障碍.
主要成果:
- 老化的线粒体显示氧化酸化减少,反应性氧物种 (ROS) 增加和DNA突变.
- 线粒体生物能和自的下降与衰老有关,原因是细胞防御和修复机制受损.
- 线粒体功能,蛋白质翻译和蛋白质稳定之间的复杂相互作用在AMD中至关重要.
结论:
- 线粒体功能障碍,自功能受损和蛋白质稳定性受损是干性AMD的关键因素.
- 相关的疾病模型对于推动AMD研究和药物开发至关重要.
- 针对线粒体功能障碍的临床试验为AMD提供了潜在的治疗策略.
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