针对COVID-19的抗病毒疗法
Georgii Gudima1, Ilya Kofiadi1,2, Igor Shilovskiy1
1NRC Institute of Immunology, Federal Medico-Biological Agency, 115522 Moscow, Russia.
International journal of molecular sciences
|May 27, 2023
概括
由于正在演变的SARS-CoV-2菌株,针对COVID-19的抗病毒药物开发至关重要. 本综述涵盖了现有和新型抗病毒疗法,包括反感性寡核酸,证明了它们对各种病毒变异的有效性.
科学领域:
- 病毒学和传染病学.
- 药理学和治疗学 药理学和治疗学
背景情况:
- 最初的COVID-19反应优先考虑了疫苗开发.
- 随着对SARS-CoV-2生物学知识的不断增长和针对新菌株的疫苗疗效下降,人们的注意力转移到了抗病毒疗法上.
- 随着COVID-19药物治疗的临床经验不断增长.
研究的目的:
- 审查COVID-19各种抗病毒疗法的机制和临床疗效.
- 总结这些药物与临床指南有关的当前状态.
- 引入针对SARS-CoV-2基因组的创新反感性寡核酸疗法.
主要方法:
- 对COVID-19抗病毒药物的安全性和有效性发表的临床数据的审查.
- 对在病毒生命周期的不同阶段起作用的药物的分析.
- 包括既有和新的治疗方法,包括反感性寡核酸.
主要成果:
- 总结了关于血衍生疗法的安全性和有效性的临床数据,单克隆抗体,干扰素,融合抑制剂,核糖类类似物和蛋白酶抑制剂.
- 该审查详细说明了根据官方COVID-19治疗指南的这些治疗方法的当前状况.
- 介绍了针对SARS-CoV-2基因组的创新反感性寡核酸.
结论:
- 目前的抗病毒药物有效地针对新出现的SARS-CoV-2菌株的广泛范围.
- 抗病毒疗法提供了对COVID-19的可靠防御.
- 对抗病毒药物发现的持续研究和开发对于管理大流行病至关重要.
关键词:
在 COVID-19 疫情中,这就是SARS-CoV-2病毒.反感的寡核化物.抗病毒疗法是一种抗病毒疗法.康复期间的血.核聚变抑制剂 核聚变抑制剂一个单克隆抗体.核酸类型的类似物.蛋白酶抑制剂是一种蛋白酶抑制剂.siRNA 是一个RNA.更多相关视频
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