炎症在红血系统年龄相关变化的作用
Eryk Wacka1, Edyta Wawrzyniak-Gramacka1, Anna Tylutka1
1Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, Poland.
International journal of molecular sciences
|May 27, 2023
概括
炎症,指的是高的互乐素-1β (IL-1β),与老年人的贫血有关. 像IL-1β,CD34和CD38这样的生物标志物可以帮助识别贫血的原因并监测其进展.
科学领域:
- 老年学是一门学科.
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 与衰老相关的贫血是严重的健康问题,导致老年人虚弱,认知能力下降和死亡率.
- 炎症是一种与衰老相关的慢性轻度炎症,越来越多地被认为是与年龄有关的疾病的一个因素.
研究的目的:
- 研究老年患者炎症和贫血之间的关系.
- 评估炎症标志物作为老年人贫血的预后指标.
主要方法:
- 对贫血 (n=47) 和非贫血 (n=66) 的老年人进行比较分析 (平均年龄为73.0±7.2岁).
- 评估血液学变量,铁状况 (包括转林和),以及促炎性细胞因子 (IL-1β,TNFα,肝素).
- 评估外周血液单核细胞标记物 (CD34,CD38) 和它们与贫血发展的关联.
主要成果:
- 贫血患者表现出较低的红细胞指数,铁和铁素,以及较高的红色素 (EPO) 和转激素 (Tf).
- 大约26%的参与者具有转林和率<20%,表明缺铁.
- 高水平的IL-1β与血红蛋白 (Hb) 有负相关性,并且与贫血有很强的关联 (OR = 72.374).
- CD34和CD38标志物也与患贫血的可能性更高相关 (OR分别为3.264和4.398).
结论:
- 在与衰老相关的贫血中,炎症状态和铁代谢之间存在明显的相互作用.
- IL-1β是一种有价值的生物标志物,可用于识别老年人贫血的原因.
- CD34和CD38可以帮助评估补偿反应和长期贫血监测.
相关概念视频
01:38Inflammation
54.0K
Overview
54.0K
01:19The Effect of Aging on Tissues
2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
01:30Inflammatory Response I: Vascular and Cellular
11.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.5K
01:26Aging
92
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
92
01:28Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
01:21Myocarditis I: Introduction
12
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
12