寄生虫感染中的NETosis:一个尚未解决的难题
1Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
International journal of molecular sciences
|May 27, 2023
概括
中性细胞外细胞陷 (NETs) 在对抗病原体方面至关重要. 这篇评论探讨了NETs.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 寄生虫学的寄生虫学
背景情况:
- 中性粒细胞是重要的先天性免疫细胞,采用各种病原体消除策略.
- 中性细胞外细胞陷 (NETs) 是DNA和蛋白质的网状结构,是关键的效应机制.
- 在细菌,病毒和真菌感染中,NET已经得到了很好的研究,但它们在寄生虫感染中的作用正在出现.
研究的目的:
- 审查在简单的捕捉之外,在对抗虫感染方面对NET的作用较少探索.
- 批判性地研究NET在原生动物感染中的影响,挑战对仅仅保护性作用的关注.
- 突出NETs在寄生虫感染中的双重性质,包括有益和病理功能.
主要方法:
- 对寄生虫感染 (虫和原生动物) 中的NET研究的文献综述.
- 对现有研究进行分析,以确定NET的研究不足的功能.
- 综合发现,提出原生动物与NET相互作用的局限性和复杂性.
主要成果:
- 网表现出对虫的多样性功能,超出了固定或陷的范围.
- 现有关于原生动物与NET相互作用的研究主要突出了保护性方面.
- 网和原生动物之间的相互作用存在局限性和复杂的功能二元性.
结论:
- 网在对抗虫的宿主防御中发挥着多方面的作用.
- 网对原生动物的保护作用可能被高估,具有显著的病理潜力.
- 需要进一步的研究来了解NETs在寄生病中的复杂且经常交织的有益和有害作用.
相关概念视频
01:15Diversity of Protists I
48
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
48
01:27Diversity of Protists II
60
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
60
01:28Fungal Phylum Microsporidia
43
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
43