和糖尿病引起的慢性病:一个定量病例对照研究
Supabhorn Yimthiang1, David A Vesey2,3, Phisit Pouyfung1
1Occupational Health and Safety, School of Public Health, Walailak University, Nakhon Si Thammarat 80160, Thailand.
International journal of molecular sciences
|May 27, 2023
概括
慢性 (Cd) 暴露会使糖尿病患者的病恶化,增加管管功能障碍和白尿的风险. 即使是低Cd水平也可以加速病在这个人群中的进展.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 慢性 (Cd) 暴露会损害近位管细胞,导致膜过率 (GFR) 降低和管状蛋白尿.
- 糖尿病病 (DKD) 的特征是白蛋白尿和GFR下降,可能导致功能衰竭.
- 对Cd暴露和糖尿病对病进展的综合影响尚不清楚.
研究的目的:
- 评估与非糖尿病对照组相比,糖尿病患者的暴露水平和管状蛋白尿和白蛋白尿的严重程度.
- 调查暴露,糖尿病和功能障碍标志物 (如管管功能障碍和白尿) 之间的关联.
主要方法:
- 一项涉及88名糖尿病患者和88名匹配对照的病例控制研究.
- 测量血液和尿液中的含量 (ECd/Ccr) 和β2-微球蛋白分泌率 (Eβ2M/Ccr),以评估管管功能障碍.
- 分析暴露,糖尿病,高血压,估计GFR (eGFR) 和病标志物之间的关联.
主要成果:
- 管管功能障碍与糖尿病和暴露有关.
- 增加的体负荷,高血压和降低的eGFR显著增加了严重管管功能障碍的风险.
- 高血压和降低的eGFR,但没有暴露,与白尿风险的增加显著相关.
结论:
- 即使低水平的暴露也会加剧糖尿病患者病的进展.
- 暴露有助于管状损伤,而高血压和降低的GFR是该人群中白尿的主要驱动因素.
- 这些发现强调了监测和减轻糖尿病患者暴露的重要性,以防止损伤.
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