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用微流体装置进行临床翻译的向微气泡的合成和评估,用于体内超声波分子成像
Rakesh Bam1, Arutselvan Natarajan1, Farbod Tabesh1
1Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
International journal of molecular sciences
|May 27, 2023
概括
研究人员使用亲体配体开发了向的微气泡 (MB),以检测乳腺癌.
科学领域:
- 生物医学工程 生物医学工程
- 分子成像学分子成像学
- 纳米技术 纳米技术
背景情况:
- 乳腺癌的诊断依赖于成像技术.
- 有针对性的分子成像剂可以提高诊断准确度.
- B7-H3受体是乳腺癌血管系统的潜在生物标志物.
研究的目的:
- 使用微流体装置合成针对B7-H3受体的微气泡 (MB).
- 评估这些MBs在乳腺癌诊断中的体外和体内向有效性.
主要方法:
- 对抗B7-H3受体的高亲和力附体配体进行了工程设计.
- 用于MB配方的基因与脂的特定位点对合.
- 针对性MBs (TMBs) 的微流体合成.
- 在小鼠模型中进行了体外流室试验和体外免疫染.
主要成果:
- 通过微流体系统成功合成了TMBs (MBB7-H3).
- 与非向的MB相比,MBB7-H3对表达B7-H3细胞和瘤血管系统具有显著更高的结合亲和力.
- 在体内研究表明,MBB7-H3与表达B7-H3.3的瘤血管的同位化.
结论:
- 一个新的,临床可翻译的B7-H3向微泡 (MBB7-H3) 用微流体学合成.
- 这些MB在体外和体内都显示出对表达血管内皮细胞的B7-H3具有显著的结合亲和力.
- MBB7-H3具有作为乳腺癌诊断分子超声波对比剂的潜力.
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