乙素颗粒蛋白与急性尾炎有关 - - 一种过敏性疾病?
Nuno Carvalho1,2, Elisabete Carolino3, Hélder Coelho4
1Serviço Cirurgia Geral, Hospital Garcia de Orta, 2805-267 Almada, Portugal.
International journal of molecular sciences
|May 27, 2023
概括
乙氨基粒蛋白,特别是乙氨基蛋白 (ECP) 和乙氨基氧化酶 (EP),在急性尾炎中升高,这表明其发病过程中存在过敏成分. 这些标志物显示出诊断尾炎的潜力,但在区分复杂病例方面效率较低.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 过敏 过敏是一种过敏.
背景情况:
- 急性尾炎可能涉及过敏触发因素,由Th2免疫反应和氨基细胞调动证明.
- 乙素脱粒和颗粒蛋白的释放是尾炎局部组织损伤的潜在贡献者.
研究的目的:
- 在局部和全身水平上评估欧素颗粒蛋白 (EDN,ECP,EP) 在急性尾炎中的作用.
- 评估这些蛋白质的诊断准确性,以检测急性尾炎,并区分复杂和不复杂的病例.
主要方法:
- 展望性研究分析了埃索诺菲尔衍生的神经毒素 (EDN),埃索诺菲尔阴性蛋白 (ECP) 和埃索诺菲尔过氧化酶 (EP) 度.
- 测量了尾洗液 (ALF) 和来自急性尾性尾炎 (APA),急性尾性尾炎 (AGA) 和健康对照患者的血清.
- 统计分析比较了不同组的蛋白质水平,并使用接收器操作特征 (ROC) 曲线评估诊断性能.
主要成果:
- 与对照组相比,急性尾炎患者 (ALF和血清) 的ECP和EP度显著更高 (p < 0.0001).
- 在ALF或血清中,APA和AGA组之间没有发现ECP或EP水平的显著差异.
- 对于ECP (>11.41 ng/mL) 和EP (>93.20 ng/mL) 的最佳切线显示出对尾炎诊断的高灵敏度但低特异性 (AUC分别为0.880和0.901).
结论:
- 尾炎中ECP和EP水平升高表明Th2型免疫反应以及过敏反应在其发病过程中的潜在作用.
- 血清ECP和EP度可以帮助诊断急性尾炎,但对区分复杂和无复杂病例的能力有限.
- 需要进一步研究这些标记物的诊断效用,特别是与其他临床发现相结合,是合理的.
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