萨尔科佩尼亚是皮肤内镜胃口切除术患者的预后因素
Shingo Ono1, Hiroto Furuhashi1, Shunsuke Kisaki2
1Department of Endoscopy, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
Journal of clinical medicine
|May 27, 2023
概括
骨肌肉质量的丧失,即萨尔科佩尼亚,显著恶化了为营养而接受皮肤内镜胃口切除术 (PEG) 的患者的预后. 在 Sarcopenia 治疗前,确定 Sarcopenia 治疗的确切性对于预测 PEG 患者的结果至关重要.
科学领域:
- 医学科学 医学科学 医学科学
- 临床营养学 临床营养学
- 老年病的医生 老年病的医生
背景情况:
- 穿皮内镜胃口术 (PEG) 是一种常见的长期肠道营养方法.
- 对于PEG患者的预后因素尚不清楚.
- 标症的特征是骨肌肉质量丧失,对PEG预后的影响尚不清楚.
研究的目的:
- 为了研究手术前的肉类和PEG.之后的患者预后之间的关联.
- 确定影响经过PEG治疗的患者整体存活期的预后因素.
主要方法:
- 在2008年3月至2020年4月期间接受PEG治疗的127名患者的回顾性分析.
- 根据CT成像使用第三个腰椎骨肌肉指数定义的萨尔科佩尼亚.
- 使用考克斯比例危险模型和倾向得分匹配分析的整体生存率.
主要成果:
- 在56%的患者 (71/127) 诊断出了萨科佩尼亚.
- 与没有 (1133天) 相比,患有肉类的患者的中位生存时间 (273天) 显著较短 (p < 0.001).
- 麻症 (aHR:2.9),低血清白蛋白和男性性别独立地与整体存活率差相关.
结论:
- 麻症是接受PEG.患者的显著负面预后因素.
- 术前评估的肉可能有助于预测PEG患者的结果.
- 需要进一步研究在这个患者群体中治疗肉类的方法.
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