肥胖与智利患者实验室生物标志物的变化有关,这些患者因COVID-19住院治疗
Sharon Viscardi1,2,3, Luis Marileo3,4, Hugo Delgado5
1Laboratorio de Investigación en Salud de Precisión, Departamento de Procesos Diagnósticos y Evaluación, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Manuel Montt 56, Campus San Francisco, Temuco 4813302, Chile.
肥胖与更高的COVID-19住院风险和改变的炎症标志物有关. 这项研究发现,肥胖与炎症和血液静止生物标志物升高相关,增加了严重COVID-19结果的可能性.
科学领域:
- 传染性疾病 传染性疾病
- 代谢障碍 代谢障碍 代谢障碍
- 临床生物化学 临床生物化学
背景情况:
- 肥胖是一个已知的COVID-19严重结局的风险因素.
- 患有肥胖症的患者因COVID-19而经历更高的住院率.
- 肥胖对COVID-19生物标志物的影响需要进一步调查.
研究的目的:
- 调查智利住院COVID-19患者的肥胖和实验室生物标志物变化之间的关联.
- 为了评估肥胖如何影响COVID-19住院期间的炎症和静血标志物.
主要方法:
- 分析了202名住院COVID-19患者的队列 (71名肥胖者,131名非肥胖者).
- 收集了人口统计,临床和连续实验室数据 (第1,3,7,15天).
- 进行了统计分析以确定显著性 (p < 0.05).
主要成果:
- 肥胖患者在慢性呼吸道病理方面表现出显著差异.
- 观察到炎症标志物 (CPR,费里丁,NLR,PLR) 的升高和白细胞计数的改变.
- 在肥胖患者中观察到持续的D-二次体升高,与重症监护,通风和更长的住院时间相关.
结论:
- 住院COVID-19患者的肥胖与明显的炎症和静血标志物升高有关.
- 肥胖与特定实验室生物标志物变化相关.
- 这些变化与COVID-19患者不良临床结果风险增加有关.
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