在精神分裂症和双极性疾病中,大脑半球不对称
Diogo Pinto1, Ricardo Martins1,2, António Macedo1,2,3
1Faculty of Medicine, University of Coimbra (UC), 3004-504 Coimbra, Portugal.
Journal of clinical medicine
|May 27, 2023
概括
大脑不对称性在精神分裂症 (SCZ) 和双相情感障碍 (BPD) 患者之间有显著差异. 这些发现可能有助于使用神经成像标记物区分这些疾病.
科学领域:
- 神经成像是一种神经成像.
- 神经精神病学是一种神经精神病学.
- 大脑解剖学 大脑解剖学
背景情况:
- 精神分裂症 (SCZ) 和双相情感障碍 (BPD) 是重叠症状的严重精神障碍.
- 了解不同的神经生物学基础对于准确的诊断至关重要.
研究的目的:
- 为了比较SCZ,BPD和健康对照 (HC) 中的大脑结构不对称.
- 调查是否不对称模式可以区分SCZ和BPD.
主要方法:
- 使用完全自动化的基于声素的形态测量 (VBM) 方法.
- 分析了60名参与者的磁共振成像 (MRI) 扫描 (20个SCZ,20个BPD,20个HC).
- 参与者是右撇子,年龄,性别和教育都匹配.
主要成果:
- 在SCZ和BPD患者之间,以及在每个患者组和HC之间观察到灰质不对称性的显著差异.
- BPD患者在特定的大脑区域 (布罗德曼区域6,11,37,前带皮层) 显示出高于SCZ患者的不对称指数 (AI).
- 在小脑中,SCZ患者的AI比BPD患者高.
结论:
- 结构性大脑不对称模式在SCZ和BPD之间有显著差异.
- 这些发现表明,MRI检测到的大脑变化可以作为差异诊断的潜在生物标志物.
- 进一步的研究可以阐明疾病特异性异常,并改善临床实践.
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