在神经临界护理中控制发烧的迪克洛芬:系统性审查
Tommaso Rochat Negro1, Michael Watchi2, Hannah Wozniak1
1Intensive Care, Hôpitaux Universitaires de Genève, 1205 Genève, Switzerland.
Journal of clinical medicine
|May 27, 2023
概括
狄克洛芬 (DCF) 有效地降低神经临界护理患者的发烧. 然而,由于证据有限,需要更多的研究来证实它对大脑参数的益处.
科学领域:
- 神经临界护理是指神经临界护理.
- 药理学 药理学 是一个学科.
- 基于证据的医学是基于证据的医学.
背景情况:
- 发烧在神经临界护理患者中很常见,并且与不良结果有关.
- 非类固醇抗炎药物 (NSAIDs) 通过抑制前列腺素E2合成来降低发烧.
- 狄克洛芬 (DCF) 是这种人群中潜在的二线发烧治疗方法.
研究的目的:
- 系统地审查二二 (DCF) 在降低体温方面的有效性.
- 评估DCF对神经临界护理患者大脑参数的影响.
主要方法:
- 在2022年11月进行了全面的数据库搜索.
- 包括从1980年起在奥维德EBM评论,科克莱恩图书馆,奥维德Medline和Scopus上发表的研究.
- 结果集中在体温控制和大脑参数变化.
主要成果:
- 从113个已识别的标题中,审查了六篇符合条件的文章.
- DCF显著降低了人体温度 (MD,1.10 [0.72,1.49],p < 0.00001). 这也使得体温下降.
- 观察到内压力 (ICP) 略有,但不显著下降,脑输液压 (CPP) 和平均动脉压 (MAP) 显著下降.
结论:
- 狄克洛芬 (DCF) 有效降低脑损伤患者的发烧.
- 目前的文献有限,具有显著的异质性和潜在的出版偏见.
- 需要进一步的研究来充分评估DCF对大脑参数的益处.
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