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随着时间的推移,异构血造干细胞移植中的输血负担:来自单一机构的经验
Pilar Solves1,2, Javier Marco-Ayala1,3, Miguel Ángel Sanz1,2
1Haematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain.
血液造血干细胞移植 (HSCT) 的输血需求并没有减少,尽管方法不断发展. 值得注意的是,匹配的相关捐赠者HSCT在近年来增加了输血负担.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 临床研究 临床研究
背景情况:
- 全基性造血干细胞移植 (HSCT) 在很大程度上依赖于输血来支持患者.
- 了解输血趋势对于优化HSCT支持性护理至关重要.
研究的目的:
- 评估随着时间的推移,不同HSCT模式的输血要求的变化.
- 评估一个机构的输血负担的演变.
主要方法:
- 855名成年HSCT患者 (2009-2020) 的临床病历和输血记录的回顾性审查.
- 根据HSCT类型分类的患者:匹配的相关捐赠者 (MRD),匹配的非相关捐赠者 (MUD),带血液移植 (UCBT) 和单一的HSCT (Haplo-HSCT).
- 数据分析跨越三个不同的时间段:2009-2012,2013-2016年和2017-2020年.
主要成果:
- 对于MUD和Haplo-HSCT在不同时间段的红细胞 (RBC) 和血小板 (PLT) 需求或输血独立性没有显著变化.
- 在最近一段时间 (2017-2020年) 中,MRD HSCT患者的输血负担显著增加.
结论:
- 尽管移植方式的进步,HSCT的整体输血需求并没有显著下降.
- 输血仍然是支持性护理的重要组成部分.
- 特定的HSCT类型,如MRD,可能会随着时间的推移而增加输血需求.
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