免疫检查点抑制剂诱导下炎的进展和挑战
Piaohong Chen1, Jianwei Li1,2, Huiwen Tan1,2
1Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Journal of clinical medicine
|May 27, 2023
概括
免疫检查点抑制剂 (ICI) 可以增强抗瘤活性,但可能导致与免疫相关的不良事件 (irAEs). 本综述侧重于免疫检查点抑制剂诱导的低性炎 (IH),一种罕见的irAE,以及其诊断和管理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 免疫检查点抑制剂 (ICI) 是一种新型抗瘤药物,可增强T细胞活性.
- ICI可以破坏自我耐受性,导致与免疫相关的不良事件 (irAEs).
- 免疫检查点抑制剂诱导的低血清炎 (IH) 是一种罕见但显著的irAE.
研究的目的:
- 在接受ICI的患者中调查IH的风险.
- 总结有关IH流行病学,病原,临床表现,诊断和治疗的当前知识.
- 突出及时IH诊断对患者结果的重要性.
主要方法:
- 对ICI和IH研究的文献综述.
- 对流行病学数据的分析.
- 综合有关临床表现,诊断标准和治疗策略的信息.
主要成果:
- IH是一种罕见的与ICI治疗相关的irAE.
- 胰腺炎的临床表现可能是非特异性的,使诊断复杂化.
- 延迟诊断IH可能导致预后不佳.
结论:
- 准确及时诊断IH对于管理ICI患者至关重要.
- 需要进行进一步的研究,以充分评估风险并优化IH的管理.
- 了解IH对于提高癌症免疫治疗的安全性和有效性至关重要.
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