黄素在自闭症谱系障碍中的新兴作用:系统性审查
Rosa Savino1, Alessandro Medoro2, Sawan Ali2
1Department of Woman and Child, Neuropsychiatry for Child and Adolescent Unit, General Hospital "Riuniti" of Foggia, 71122 Foggia, Italy.
Journal of clinical medicine
|May 27, 2023
概括
黄类药物通过减少氧化应激和炎症来改善自闭症谱系障碍 (ASD) 症状. 虽然临床前研究令人鼓舞,但需要更严格的临床试验来确认它们在人类中的有效性.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,通常与氧化应激和炎症有关.
- 植物衍生化合物黄酸具有已知的抗氧化,抗炎和神经保护性质.
研究的目的:
- 系统地审查与自闭症谱系障碍相关的临床前和临床研究中关于黄类药物影响的现有证据.
- 评估黄类药物作为治疗ASD特征的治疗策略的潜力.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了系统的文献搜索,遵守PRISMA指南.
- 包括的研究包括17项临床前研究和4项临床研究,检查ASD模型或个体中的黄类干预措施.
主要成果:
- 临床前研究表明,黄类药物可以改善氧化应激标志物,减少炎症并增强神经发生.
- 动物模型表明,黄类药物可以改善ASD核心症状,包括社会缺陷,重复性行为和认知障碍.
- 来自开放标签研究的初步临床数据表明,使用特定的黄类药物 (如醇和氨酸) 可能会改善行为,但缺乏随机对照试验.
结论:
- 本综述提供了第一个系统证据,表明黄类药物对自闭症谱系障碍特征的潜在益处.
- 从临床前和有限的临床数据中得到的有希望的发现,需要通过精心设计的随机对照试验进行进一步的研究,以确定临床疗效.
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