在子宫内膜异位症中同时发生的自身免疫损害了子宫内膜-胚胎在植入部位的交叉交流:一个多中心病例对照研究
Noemi Salmeri1, Gianluca Gennarelli2, Valeria Stella Vanni1
1Gynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Journal of clinical medicine
|May 27, 2023
概括
患有子宫内膜异位症和自身免疫性疾病的女性的胚胎植入率较低. 同时存在的自身免疫显著恶化生殖结果,影响生育治疗.
科学领域:
- 生殖免疫学 生殖免疫学
- 不孕症的研究研究.
- 自免疫性疾病对生殖的影响.
背景情况:
- 子宫内膜异位症和自身免疫性疾病共享超炎症状态.
- 免疫失调可以损害子宫内膜受体和胚胎能力.
- 对早期生殖的综合影响尚未完全理解.
研究的目的:
- 为了研究自身免疫在患有子宫内膜异位症的妇女在早期生殖阶段的额外影响.
- 评估对体外受精-胚胎移植 (IVF-ET) 结果的影响.
主要方法:
- 对接受IVF-ET (2007-2021) 的妇女进行了回顾性多中心病例控制研究 (N=600).
- 病例:具有自身免疫性的子宫内膜异位症;对照:仅仅是子宫内膜异位症.
- 根据年龄和BMI进行匹配;主要结果:累计临床怀孕率 (cCPR).
主要成果:
- 在病例中,切割率 (p=0.042) 和植入率 (p=0.029) 显著降低.
- 自身免疫力 (p=0.018),年龄和反应不佳预测了较低的cCPR.
- 自免疫性调整后的几率比:0.54 (95% CI,0.33-0.90).
结论:
- 在子宫内膜异位症的同时发生的自身免疫性显著且增加地降低了胚胎植入率.
- 免疫和炎症机制可能会干扰子宫内膜受体和胚胎发育.
- 为了改善生育结果,需要对这些机制进行进一步的研究.
关键词:
这是自抗体的自抗体.自体免疫性是一种自身免疫性.胚胎发育过程中的胚胎发育.子宫内膜异位症是什么?子宫内膜异位症是什么植入植入植入植入植入植入植入植入植入怀孕率 怀孕率 怀孕率生殖内分泌学 生殖内分泌学更多相关视频
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