在患有胸腔大动脉动脉瘤的患者中"Vasa Vasorum"的情况
Petr V Chumachenko1,2, Alexandra G Ivanova1, Mariam Bagheri Ekta1
1Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia.
Journal of clinical medicine
|May 27, 2023
概括
炎症细胞和血管 (小血管) 在胸前大动脉动脉瘤的发展中起着至关重要的作用. 血管管道的病理变化,包括T细胞透和血栓,显著损害了大动脉壁的血液供应.
科学领域:
- 心血管生物学 心血管生物学
- 免疫学 免疫学 免疫学
- 血管病理学血管病理学
背景情况:
- 血管 (VV) 供应了上升的胸前大动脉的外部三分之一.
- 大动脉动脉瘤病原体中VV的作用尚未完全理解.
- 炎症细胞透是大动脉动脉瘤的一个标志.
研究的目的:
- 为了研究胸前大动脉动脉瘤中炎症细胞和vasa vasorum之间的关系.
- 评估Vasa vasorum病理对大动脉壁血液供应对动脉瘤患者的影响.
主要方法:
- 胸前大动脉动脉瘤活检的免疫组织化学分析 (n=48).
- 使用的抗体:T细胞 (CD3,CD4,CD8),巨细胞 (CD68),B细胞 (CD20),内皮细胞 (CD31,CD34,vWF),光滑肌细胞 (alpha actin).
- 在具有或没有炎症透物样本中比较vasa vasorum特征.
主要成果:
- 具有炎症透的样本在突前进管中具有显著较少的血管 (vasa vasorum) (p < 0.05).
- 在28/48名患者中,T细胞附着于血管内皮,在炎症患者中更为普遍 (p < 0.0006).
- 在大量患者中,Vasa vasorum表现出高,硬化,光层狭窄,T细胞透和血栓形成,损害了大动脉壁 perfusion.
结论:
- 血管的状态在胸前大动脉动脉瘤的发展中至关重要.
- 血管中的病理变化,包括炎症细胞透和血栓形成,对大动脉动脉瘤的发病有显著的贡献.
- 通过血管血管的血液供应受损是大动脉壁退化的一个关键因素.
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