用PASCAL与MitraClip进行边缘到边缘跨导管中枢修复:系统性审查和元分析
Kaveh Hosseini1,2, Hamidreza Soleimani1,2,3, Amir Nasrollahizadeh1,2
1Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1419733141, Iran.
Journal of clinical medicine
|May 27, 2023
概括
帕斯卡和MitraClip设备在腹反 (MR) 的跨导管端到端修复 (TEER) 中表现出类似的有效性,在分析中显示出相似的成功率和并发症概况.
科学领域:
- 心血管干预 心血管干预
- 医疗器械技术 医疗器械技术
- 比较临床研究比较临床研究
背景情况:
- 过导管边缘到边缘修复 (TEER) 是对额头回 (MR) 的关键治疗方法.
- 对于TEER,PASCAL和MitraClip设备被广泛使用.
- 这些设备的对比比较是有限的.
研究的目的:
- 进行一项元分析,比较PASCAL和MitraClip设备对TEER的临床结果.
- 评估PASCAL与MitraClip在患有严重MR的患者中的疗效和安全性.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Cochrane) 和临床试验注册表中进行了系统的文献搜索.
- 包括随机对照试验和观察性研究,比较PASCAL和MitraClip的TEER在严重的MR中.
- 关键结果包括MR减少,NYHA功能类改进和死亡率.
主要成果:
- 对785名 (PASCAL) 和796名 (MitraClip) 患者的数据分析显示,同样的30天全因死亡率和MR减少到2+或以下.
- 两种设备都显示出高且可比的成功率 (超过96%) 和在放电时MR减少到1+或以下的类似率.
- 综合的临床和住院死亡率,以及脑血管疾病的发病率在PASCAL的数字上较低,尽管在统计学上并不显著.
结论:
- 无论是PASCAL还是MitraClip设备,都对中枢的TEER有效且安全.
- 在实现在放电时减少MR方面,PASCAL设备与MitraClip设备无差.
- 这两种设备的成功率都很高,并发症概况也很低.
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