来自肠道微生物群的短链脂肪酸:肠道色胺转运体的新型调节剂
Berta Buey1, Ana Forcén2, Laura Grasa1,3,4
1Departamento de Farmacología, Fisiología y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain.
Life (Basel, Switzerland)
|May 27, 2023
概括
发现肠道微生物群的副产品称为短链脂肪酸 (SCFA),可以调节肠道.
科学领域:
- 神经胃肠病学和肠道微生物组研究
- 分子和细胞生物学分子和细胞生物学
- 神经科学和神经药理学 神经科学和神经药理学
背景情况:
- 血清素 (5-HT) 是中枢神经系统和肠道中关键的神经递质,影响情绪,认知和胃肠功能.
- 中毒素转运体 (SERT) 调节细胞外中毒素水平,通过各种中毒素受体 (5-HTRs) 影响其信号传递.
- 肠道微生物群可以影响血清激素信号传递,但微生物代谢物如短链脂肪酸 (SCFA) 的具体作用尚不清楚.
研究的目的:
- 研究由肠道微生物群产生的SCFA对胃肠道血清系统的影响.
- 确定SCFA是否调节肠道细胞中血清素转运体 (SERT) 和特定血清素受体 (5-HTRs) 的功能和表达.
主要方法:
- 利用了Caco-2/TC7细胞系,它构成性地表达SERT和各种5-HTRs.
- 处理的细胞具有不同度的SCFA (propionate,乙酸盐,丁酸盐).
- 评估了SERT的功能和表达,以及5-HT受体1A,2A,2B,3A,4和7的表达.
主要成果:
- 微生物群衍生的SCFA,单独或组合,已被证明可以调节肠道的血清代谢系统.
- SCFA 调节了 SERT. 的功能和表达.
- 观察到5-HT受体表达的显著调节,特别是5-HT1A,5-HT2B和5-HT7.
结论:
- 肠道微生物群代谢物 (SCFA) 在调节肠道血清系统方面发挥着直接作用.
- 这些发现凸显了肠道微生物群对肠道平衡的影响.
- 微生物组调节为肠道病理和与血清素失调相关的神经精神疾病提供了潜在的治疗途径.
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