COVID-19和多发性硬化症患者的健康结果:意大利的一项基于人口的研究
Roberto Gnavi1, Ilenia Eboli1, Paolo Emilio Alboini2
1Epidemiology Unit, ASL TO3 Regione Piemonte, 10095 Grugliasco, Italy.
Life (Basel, Switzerland)
|May 27, 2023
概括
多发性硬化症 (PWMS) 患者在COVID-19大流行期间面临住院和ICU入院风险较高. 虽然抽样检测更频繁,但COVID-19感染率与普通人口相似.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,COVID-19大流行严重扰乱了医疗保健服务.
- 患有多发性硬化症 (PWMS) 的人可能会不成比例地受到这些干扰的影响.
- 了解大流行对PWMS的影响对于医疗保健规划至关重要.
研究的目的:
- 评估COVID-19大流行对PWMS健康结果的影响.
- 为了比较PWMS和无多发性硬化症个体之间的COVID-19相关结果.
主要方法:
- 意大利皮埃蒙特的一个队列研究,将9333名PWMS与4,145,856名无MS个体进行比较.
- 数据与电子健康记录,COVID-19注册,医院出院和人口注册的数据链接.
- 经对混因子进行调整后勤回归分析,以评估样本检测,住院,ICU入院和死亡等结果.
主要成果:
- 与没有MS的受试者相比,PWMS显示了更高的抽样检测率,但与COVID-19阳性相似.
- 在PWMS患者中,住院的风险显著增加 (OR=1.74) 和ICU入院的风险显著增加 (OR=1.79).
- 在PWMS中观察到轻微的,非统计学上显著的死亡率增加 (OR=1.28).
结论:
- 与一般人群相比,患有COVID-19的PWMS经历了住院和ICU入院的风险增加.
- 在PWMS和普通人群之间,死亡率没有显著差异.
- 这些发现强调了PWMS对严重COVID-19结果的脆弱性,需要有针对性的健康策略.
相关概念视频
Factors Affecting Illness
4.3K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.3K
Bias in Epidemiological Studies
388
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
388
COPD: Pathogenesis and Clinical Features
371
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
371
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
Psychoneuroimmunology: Cardiovascular Disease
57
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
57
Rous Sarcoma Virus (RSV) and Cancer
5.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.2K


