溶解方法的进步:迈向提高难溶性药物的生物可用性的一步
Lakshmi Kumari1, Yash Choudhari1, Preeti Patel2
1Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga 142001, Punjab, India.
Life (Basel, Switzerland)
|May 27, 2023
概括
药物的溶解性差,阻碍了新药的研发. 本综述涵盖了物理,化学和纳米技术方法,以提高药物的溶解性和生物可用性,尽管广泛应用仍然存在挑战.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 药用化学 医学化学
背景情况:
- 水溶性差是药物开发中的一个重大挑战,影响高达90%的候选药物.
- 溶解度低导致生物可用性降低,治疗疗效降低,剂量要求增加.
- 解决溶解度对于成功的制药产品开发和患者的治疗结果至关重要.
研究的目的:
- 审查和总结常规和先进的方法,以提高难溶性药物的可溶性.
- 提供药物研究中使用的物理,化学和纳米技术策略的概述.
- 突出可溶性增强对药物的生物可用性和治疗有效性的影响.
主要方法:
- 物理方法:颗粒大小减小,固体分散,超临界流体技术,冷技术,纳入复合体形成,浮颗粒.
- 化学修饰:原药,盐形成,共同结晶,共同溶剂,水缩,多态,无形固体分散,pH调整.
- 纳米技术策略:脂质体,纳米颗粒,树脂体,,金属有机框架,纳米凝,纳米乳液,纳米悬浮,碳纳米管.
主要成果:
- 各种技术有效地提高了水溶性较差的药物的溶性,提高了口服生物可用性.
- 物理,化学和纳米技术方法提供了各种各样的策略来克服可溶性限制.
- 尽管取得了进展,但大规模生产的可重复性等挑战仍然存在,限制了普遍应用.
结论:
- 提高药物溶解度对于开发有效药品至关重要.
- 需要结合现有和新的方法来完全解决可溶性问题.
- 需要进一步的研究来简化当前技术并提高其商业可行性.
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