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跨电刺激用于关联性记忆增强:从基础到临床研究的最先进技术

Jovana Bjekić¹, Milica Manojlović¹, Saša R Filipović¹

¹Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia.

Life (Basel, Switzerland)

|May 27, 2023

概括

非侵入性大脑刺激,特别是跨电刺激 (tES),显示了增强关联记忆 (AM) 的前景. 当tES针对状皮质进行暗示回忆任务时,观察到最优的结果.

科学领域:

神经科学是一个神经科学.
认知心理学认知心理学
神经调节是一种神经调节.

背景情况:

关联记忆 (AM) 涉及将信息绑定成复杂的表示.
非侵入性大脑刺激 (NIBS),特别是跨电刺激 (tES),正在越来越多地研究AM.
研究涵盖了基础和临床研究,包括健康的成年人,老龄化人口和认知障碍患者.

研究的目的:

系统地审查有关协会记忆的tES的当前知识.
综合来自不同研究设计和人群的研究结果.

主要方法:

按照PRISMA指南进行系统的文献审查.
分析了41项使用各种tES协议 (tDCS,tACS,otDCS,HD-tDCS,HD-tACS) 的研究.
包括对健康的年轻人,老龄化人口和轻度认知障碍 (MCI) 或阿尔茨海默氏症痴呆症患者的研究.

主要成果:

在各个研究中发现了显著的方法异质性.
tES显示了增强关联记忆的潜力.
周围皮层刺激与有线回忆范式相结合,产生了有希望的效果.

结论:

超电刺激是一种有前途的神经调节技术,用于协会性记忆增强.
准头皮层似乎特别有效.
需要进一步的研究来解决方法异质性和优化协议.

关键词:

老化的老化衰老的老化关联性记忆 (AM) 是一种记忆方式.有关召回的 cued 召回痴呆症痴呆症是一种痴呆症.轻度认知障碍 (MCI) 是一种轻度认知障碍.振荡式横直流刺激 (otDCS) 是一种顶层皮质 (parietal cortex) 是一个表面皮质.通过骨交替刺激 (tACS) 进行.跨直流刺激 (tDCS) 是一种跨电刺激 (tES) 是一种

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