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难以治疗的病原体:对抗多种药物耐药性葡萄球菌表皮菌的管理进行审查
Valentina Siciliano1, Rosa Anna Passerotto2, Marta Chiuchiarelli2
1Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Life (Basel, Switzerland)
|May 27, 2023
概括
耐多药性葡萄球菌表皮病 (MDRSE) 导致具有挑战性的感染. 本综述涵盖了MDRSE流行病学,诊断和治疗,突出了知识差距和有效的患者护理管理策略.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 耐多药杆菌表皮菌 (MDRSE) 构成重大威胁,导致难以治疗的人类和医院获得的感染.
- 在S. epidermidis中,甲素耐药性可能高达92%,因此需要全面了解其耐药性模式.
研究的目的:
- 审查MDRSE感染的流行病学,微生物学,诊断和治疗.
- 识别当前了解和管理MDRSE感染的知识差距.
- 提供当前治疗选择和管理策略的概述.
主要方法:
- 使用搜索术语的文献综述,例如"泛耐药的 Staphylococcus epidermidis"和"多药耐药的 Staphylococcus epidermidis 血统".
- 分析了64个已识别的记录,重点关注流行病学,耐药性机制和临床管理.
- 综合来自培养,质谱和基因组分析的信息.
主要成果:
- 在S. epidermidis中报告的甲素耐药性高患病率 (高达92%)
- 分子工具有助于识别S. epidermidis及其抵抗机制,特别是在血液培养物中.
- 从血流感染 (BSI) 区分殖民仍然是一个临床挑战,需要考虑多个患者和生物体的因素.
结论:
- 范科米辛是主要的经验性亲肠道疗法,其替代品包括泰科普拉宁,达普托米辛等.
- 移除设备是与内置医疗设备相关的感染的一个关键考虑因素.
- 进一步的研究对于完善MDRSE感染的管理策略至关重要.
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