低兴奋值阻断性睡眠呼吸暂停表现与身体脂肪和水分发的关联
Wen-Hua Hsu1, Cheng-Chang Yang2,3,4, Cheng-Yu Tsai5,6
1School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Life (Basel, Switzerland)
|May 27, 2023
概括
患有阻塞性睡眠呼吸暂停和低兴奋值 (低ArTH) 的人通常会增加体脂和水分保留. 这些因素,特别是骨干脂肪和细胞外水,与患有低ArTH阻塞性睡眠呼吸暂停 (OSA) 的风险更高有关.
科学领域:
- 睡眠医学 睡眠医学
- 心血管呼吸系统生理学
- 肥胖问题研究研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 具有低唤醒值 (低ArTH) 的表型,可以由于轻微的呼吸系统事件而加剧睡眠碎片化.
- 虽然人类特征被怀疑会影响低ArTH OSA风险,但具体的关联和机制仍未得到充分研究.
研究的目的:
- 调查OSA患者体脂肪和水分和多睡眠学参数之间的关系.
- 为了确定与低ArTH OSA表型相关的人类学预测因素.
主要方法:
- 来自睡眠中心数据库的多睡眠学数据的回顾性分析.
- 基于氧度,呼吸事件频率和类型的低ArTH OSA的分类.
- 使用平均值比较和回归模型进行统计分析,对性别,年龄和BMI进行调整.
主要成果:
- 与非OSA组 (n=368) 相比,低ArTH OSA组 (n=1850) 年龄较大,表现出较高的内脏脂肪,身体脂肪百分比,干部与四肢脂肪比率以及细胞外与细胞内 (E-I) 水分比率.
- 经过调整后的分析显示,身体脂肪百分比 (OR: 1.58),干与四肢脂肪比率 (OR: 1.22) 和E-I水比率 (OR: 1.32) 与低ArTH OSA风险之间存在显著的关联.
- 增加骨干脂肪和细胞外水被确定为与风险增加相关的关键因素.
结论:
- 干部脂肪增加和细胞外水显著与患低ArTH OSA的风险更高有关.
- 这些发现凸显了人体构成在理解低ArTH OSA的病理生理学的重要性.
- 对这些关联的进一步研究可能会为OSA管理提供有针对性的干预措施.
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