针对软组织肉瘤的向治疗
Anne Iren Riskjell1, Vivi-Nelli Mäkinen1, Birgitte Sandfeld-Paulsen2
1Faculty of Health, Aarhus University, 8000 Aarhus C, Denmark.
Journal of personalized medicine
|May 27, 2023
概括
针对性疗法在晚期软组织肉瘤 (STS) 中表现有前途. 在患有特定基因变异的患者中,MDM2抑制剂显示出持续稳定的疾病或更好的反应.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 软组织肉瘤 (STS) 是一种罕见且异质的癌症.
- 先进的STS具有有限的治疗选择和高死亡率.
研究的目的:
- 审查针对高级STS的向治疗的临床经验.
- 评估针对STS患者特定遗传变化的治疗方法.
主要方法:
- 在PubMed和Embase数据库的系统文献搜索.
- 使用ENDNOTE和COVIDENCE进行数据管理.
- 对文献进行选,以确定患者的资格.
主要成果:
- 80名患有晚期STS的患者接受了28种不同的向药物.
- MDM2 抑制剂显示出有前途的结果,所有患者的病情稳定或更好.
- 其他药物,如crizotinib和ceritinib,表现出不同的反应.
结论:
- 向药物可以有效地解决先进的STS中的特定遗传改变.
- MDM2 抑制剂代表了高级 STS 的有前途的治疗策略.
- 由于病例报告和小群体的证据水平较低,需要进一步研究.
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