在接受紧急拉皮切除术的患者中,预后血清炎症生物标志物
Michael George1,2, Rajarshi Mukherjee1,2
1Liverpool EmerGenT Academy, Department of Emergency General and Major Trauma Surgery, Aintree University Hospital, Liverpool University Hospitals NHS Foundation Trust, Lower Lane, Liverpool L9 7AL, UK.
Journal of personalized medicine
|May 27, 2023
概括
炎症,一种与衰老相关的慢性炎症,会影响手术结果. 在入院前,红细胞沉积率 (ESR) 和淋巴细胞计数 (LC) 的升高预测,在接受紧急腹腔切除术的老年人中,关键护理停留时间更长.
科学领域:
- 老年人手术是一门老年手术.
- 炎症医学是一种炎症医学.
- 手术预测手术预测
背景情况:
- 人口老龄化在手术风险分层方面存在挑战.
- 缺乏可靠的生物标志物来预测老年手术患者的结果.
- 炎症,衰老的慢性炎症状态,可能与不良的手术结果相关.
研究的目的:
- 评估患病前的炎症标志物,以预测接受紧急腹腔切除术的老年人的预后.
- 在这个患者群体中确定风险分层的潜在生物标志物.
- 探索炎症标志物和术后结果之间的关联.
主要方法:
- 对65岁以上接受紧急腹腔切除术 (2017-2022) 的患者进行了回顾性观察研究.
- 治疗前和急性炎症标志物的分析:C反应蛋白 (CRP),红细胞沉积率 (ESR),白细胞计数 (WCC),中性粒细胞计数 (NC) 和淋巴细胞计数 (LC).
- 与国家紧急 laparotomy 审计 (NELA) 风险评分和术后结果的相关性.
主要成果:
- 分析了196名患者 (平均年龄为74.5岁) 的队列.
- 高风险和脆弱的患者在医院和重症监护室停留时间明显长 (p < 0.05).
- 在入院前ESR (≥16) 和LC (≥4.1) 的升高与更长的重症监护停留有显著关联 (p <0.05). CRP,WCC和NC没有显示任何统计学意义.
结论:
- 患病前ESR和LC升高可能会识别"炎症性"队列,在紧急腹腔切除术后结果更差.
- 这些标志物显示出老年手术患者风险分层的潜力.
- 老年手术患者的预后仍然是未来研究的关键领域.
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