性差异与死亡率和器官功能障碍的关联在患有败血症和败血症休克的患者中
Caspar Mewes1,2, Julius Runzheimer1,3, Carolin Böhnke1
1Department of Anesthesiology, University Medical Center Goettingen, 37075 Goettingen, Germany.
Journal of personalized medicine
|May 27, 2023
概括
患有败血症的男性体验到比女性更大的器官功能障碍,尽管死亡率相似. 这表明败血症严重程度和管理需求的性别差异.
科学领域:
- 关键护理医学 关键护理医学
- 败血症病理生理学病理生理学
- 疾病中的性别差异.
背景情况:
- 败血症和败血性休克仍然是导致死亡的主要原因,尽管护理方面取得了进展.
- 性对败血症结果的影响尚未完全理解,仍在争论中.
- 这项研究探讨了性别在败血症死亡率和器官功能障碍中的有争议的作用.
研究的目的:
- 调查患者性别与败血症死亡率之间的关联.
- 为了评估性差异的器官功能障碍在败血症患者.
- 探索潜在的性别特异因素影响败血症的严重程度.
主要方法:
- 预计将招募737名患有败血症或败血性休克的患者.
- 从德国哥廷根大学医学中心的三个重症监护病房收集的数据.
- 主要结局:28日和90天死亡率;次要结局:通过SOFA分数和实验室参数的器官功能障碍.
主要成果:
- 男性和女性患者在28或90天死亡率上没有显著差异.
- 男人表现出明显更高的序列器官衰竭评估 (SOFA) 评分,表明更大的器官功能障碍.
- 与女性相比,男性的SOFA呼吸和子子分数较高,胆红素和肌素水平较高,尿量较低.
结论:
- 在败血症患者中观察到器官功能障碍的显著性别差异.
- 男性患者在多种临床指标中表现出更明显的器官功能障碍.
- 研究结果表明,性别影响败血症的严重程度,可能需要量身定制的治疗策略.
相关概念视频
Factors Affecting the Risk of Infection
12.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.1K
Pneumonia III: Complications and Assessment
289
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
289
Acute Kidney Injury III: Clinical Manifestations
45
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
45
Comparing the Survival Analysis of Two or More Groups
229
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
229
Blood Pressure Imbalances and Circulatory Shock
822
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
822
Acute Kidney Injury II: Pathophysiology
37
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
37


