儿童多重全身麻醉:对其对神经发育影响的系统审查
Giacomo Colletti1,2, Mattia Di Bartolomeo3, Sara Negrello4
1Department of Medical and Surgical Sciences for Children & Adults, Cranio-Maxillo-Facial Surgery, University of Modena and Reggio Emilia, Largo del Pozzo 71, 41124 Modena, Italy.
幼儿时期的多重全身麻醉 (mGA) 可能会增加神经发育迟缓的风险. 这一系统性审查强调了潜在的风险,强调了对接受mGA的年轻患者的益处与风险的仔细考虑.
科学领域:
- 儿科麻醉学 儿科麻醉学
- 发育神经科学的发展神经科学.
- 公共卫生 公共卫生
背景情况:
- 生命早期的多重全身麻醉 (mGA) 是一个越来越令人担忧的问题,促使监管机构发出警报.
- 了解mGA在4岁以下儿童的神经发育影响至关重要.
研究的目的:
- 系统地审查关于mGA在4岁以下儿童神经发育影响的文献.
- 综合证据关于与早期接触mGA相关的潜在风险.
主要方法:
- 在Medline,Embase和Web of Science数据库中进行了系统的文献搜索,截至2021年3月31日.
- 包括专注于四岁以下接受mGA的儿科患者的研究,不包括病例报告,动物研究和专家意见.
- 在最终分析中包括了10项研究,评估了超过275,000名儿童 (11,027例暴露).
主要成果:
- 大多数包括在内的研究表明,mGA在4岁前与神经发育迟缓之间存在潜在的关联.
- 只有一项研究发现,暴露和未暴露儿童之间的神经发育结果没有统计学上显著的差异.
- 显著的队列规模表明,神经发育风险增加的潜在趋势.
结论:
- 来自受控研究的证据表明,在四岁之前接受mGA的儿童可能面临神经发育迟缓的风险.
- 这些发现强调了小儿病患者需要多次麻醉暴露时仔细评估风险和益处的重要性.
- 进一步的研究可能是有必要的,以充分阐明早期mGA的长期神经发育后果.
更多相关视频
06:38Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity AIDN: A Translational Neuroscience Approach
Published on: June 11, 2017
08:49Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
相关概念视频
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Parenteral Anesthetics: Overview
Stages of General Anesthesia
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Inhalational Anesthetics: Overview
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
