来自罗马尼亚东北部的一家紧急外科病房的Clostridium difficile感染
Bogdan Mihnea Ciuntu1, Gheorghe G Balan2, Mihaela Buna-Arvinte1
1Department of General Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Universitatii Street, No. 16, 700115 Iasi, Romania.
Medicina (Kaunas, Lithuania)
|May 27, 2023
概括
难治性结肠炎很少需要手术,但当它发生时,结果很差. 需要进行肠切除或截肢等干预的爆发性病例的死亡率很高.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 传染性疾病 传染性疾病
背景情况:
- 困难杆菌感染 (CDI) 会导致从轻度到重度的结肠炎.
- 爆发性CDI需要手术干预,但最佳的手术策略仍然不清楚.
- CDI是一个重要的医疗保健问题,特别是在手术患者中.
研究的目的:
- 为了调查Clostridium difficile大肠炎患者手术干预的发生率和结果.
- 为了确定与手术治疗的CDI患者的死亡率相关的因素.
- 评估二次手术对CDI并发症的必要性和影响.
主要方法:
- 这是一项为期3年的前性研究,针对两家外科诊所诊断出CDI的患者.
- 数据收集包括患者人口统计学,手术指示,抗生素使用,毒素类型和术后结果.
- 分析的重点是死亡率和需要额外的外科手术程序.
主要成果:
- 在12,432名手术患者中,有140名 (1.12%) 患有CDI.
- 对CDI患者的整体死亡率为14% (20例).
- 没有幸存者的截肢,肠切除,肝切除和脊髓切除率较高. 二次手术与100%的30天死亡率有关.
结论:
- 对CDI的手术干预是罕见的,但与高死亡率有关.
- 在接受结肠手术或肢体截肢的患者中,发现了CDI发病率的增加.
- 对于CDI并发症的二次手术干预具有严重的预后.
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