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产前暴露于双A:双A在第二个三个月的羊水和胎儿生长之间是否存在关联?

Nikolaos Loukas¹, Dionysios Vrachnis², Nikolaos Antonakopoulos³

¹Department of Obstetrics and Gynecology, Tzaneio General Hospital, 185 36 Piraeus, Greece.

Medicina (Kaunas, Lithuania)

|May 27, 2023

概括

孕妇在怀孕早期接触到双A (BPA) 可能会增加胎儿出生体重百分位数,并降低孕期妊娠年龄. 这种内分泌干扰剂与胎儿生长的改变有关,影响围产期的结果.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
围产儿医学围产儿医学

背景情况:

胎儿生长异常与不良的围产期和长期健康结果有关.
双A (BPA) 是一种内分泌干扰化学物质,人类广泛接触.
乙的雌激素模仿,表观遗传和遗传毒性质引起了对子宫内发育的担忧.

研究的目的:

调查母亲暴露于双A (BPA) 与胎儿异常生长速度之间的关联.
为了确定羊水中的BPA水平是否与胎儿生长参数 (如出生体重和妊娠年龄) 相相关.

主要方法:

从35名怀孕第二季度初的妇女身上采集了羊水样本.
样品使用气色谱-质谱分析分析了双甲 (BPA) 度.
根据出生体重,怀孕被分为适当的 (AGA),小 (SGA) 和大 (LGA) 怀孕年龄组.

主要成果:

在80%的羊水样本中检测到双甲 (BPA),其中位数度为281.495 pg/mL.
在羊水中BPA度和出生体重百分位数 (p=0.039) 之间发现了显著的正相关性.
在满期怀孕中,BPA水平与妊娠年龄有显著的反向关联 (p=0.031).

结论:

孕妇在怀孕早期接触到双A (BPA) 可能与出生体重百分比的增加有关.
暴露于BPA也可能有助于降低妊娠年龄在到期的怀孕.
这些发现凸显了BPA暴露对胎儿发育和出生结果的潜在风险.

关键词:

双 A 是一种双.胚胎液是什么意思胚胎液是什么意思出生的体重出生时的体重.干扰内分泌的化学物质是干扰内分泌的.过度增长是一种过度增长.胎儿生长限制限制胎儿生长这是一种炎症炎症炎症炎症.限制子宫内生长限制子宫内生长对于妊娠年龄来说很大.对于怀孕年龄来说小.

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