非雄激素药物对精液特征,氧化应激和炎症参数的影响
Gerardo Salerno1,2, Marina Borro1,2, Vincenzo Visco3
1Laboratory of Clinical Biochemistry, Sant'Andrea University Hospital, 00189 Rome, Italy.
Medicina (Kaunas, Lithuania)
|May 27, 2023
概括
药物可能通过影响炎症生物标志物影响男性不孕症. 这项研究发现,在服用各种药物的男性中,某些介质白血素 (IL) 的水平较低,这表明药物使用和不孕症炎症之间存在联系.
科学领域:
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 异形男性不孕症影响全球众多夫妇.
- 氧化应激和炎症都与男性不孕症的发病有关.
- 常见药物对不孕男性这些因素的影响尚未完全理解.
研究的目的:
- 为了研究药理治疗对氧化应激,炎症生物标志物和异常不孕症男性精液质量的影响.
- 为了比较服用药物的男性和对照组之间的这些参数.
主要方法:
- 观察性病例对照研究,涉及50名患有异常不孕症的男性 (38名服用药物,12名对照).
- 按药物类型分类的药物组:抗高血压药,甲状腺素,NSAID,各种,降脂.
- 精液分析 (世卫组织2010年),炎症性细胞因子 (ILs,TNF-alpha),氧化应激标志物 (d-ROMs) 和功能标志物 (β-2-微型血球蛋白,囊素-C) 被评估.
主要成果:
- 研究组和对照组之间在年龄或精液特征上没有显著差异.
- 与对照组相比,在接受药物治疗的组中,介质素-1α (IL-1α) 和介质素-10 (IL-10) 的水平显著降低.
- 在特定药物亚组 (A,B,C,D) 中,IL-10也显著降低.
- 在IL-1α,IL-10,TNF-α和白细胞之间观察到正相关性.
结论:
- 尽管存在局限性,但研究结果表明,在患有异常不孕症的男性中,药物消费和炎症反应激活之间存在相关性.
- 这可能会阐明某些药物类别影响男性生殖健康的致病机制.
- 需要对更大的队列进行进一步的研究来证实这些关联.
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