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Updated: Jul 29, 2025

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

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聚合的氨基基胺在Uperin-分子动力学模拟

Elena Ermakova1, Olga Makshakova1, Rauf Kurbanov1

  • 1Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, Lobachevsky Str., 2/31, Kazan 420111, Russia.

Molecules (Basel, Switzerland)
|May 27, 2023
PubMed
概括

乌佩林3.5,一个来自托德莱特的,显示了抗微生物和amyloidogenic特征. 分子动力学揭示了它的快速β-聚合,受突变物中的电荷和疏水性影响.

关键词:
聚合方式 聚合方式 聚合方式粉样蛋白类.分子动力学模拟,分子动力学模拟在Uperin上使用.

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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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