与ZnCl2结合的英多尔-伊米达复合物的合成,结构和生物活性:协调可以增强生物活性联体的功能吗?
Karolina Babijczuk1, Beata Warżajtis2, Justyna Starzyk3
1Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Molecules (Basel, Switzerland)
|May 27, 2023
概括
新型的英多尔-意米达配合物与Zn (II) 离子协调,形成新的复合物. 这些复合物表现出增强的细胞保护活性,与Trolox相似,具有抗氧化剂的潜力.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 印度尔-伊米达混合体连体被探索,因为它们的协调能力.
- (II) 复合物正在研究其潜在的生物功能.
- 了解新型协调化合物中的结构-活性关系至关重要.
研究的目的:
- 为了合成和表征新型Zn(II) 复合物与英多尔-伊米达杂交配体.
- 研究这些复合物的结构性质和超分子组合.
- 评估生物活性,包括细胞保护性,溶血性,抗真菌性和抗菌性作用.
主要方法:
- 使用ZnCl2和各种英多尔-胺达连接物合成六种新型Zn(II) 复合物.
- 通过NMR,FT-IR,ESI-MS,元素分析和单晶X射线衍射进行结构和光谱表征.
- 生物查血液溶解,细胞保护,抗真菌和抗菌活性.
主要成果:
- 成功合成和结构性表征了五个Zn (II) 复合体,揭示了通过N-H (Indole) ∙∙∙∙Cl (Chloride) 键形成的极性超分子聚合物.
- 综合体1-5呈现出多样化的分子形状,无论是紧的还是延伸的,影响了它们的组装.
- 与ZnCl2的复合显著增强了母因道尔/伊米达联体的细胞保护活性,达到与抗氧化剂Trolox相当的水平.
结论:
- 这项研究成功地开发了新的Zn(II) 协调化合物,其中含有英多尔-伊米达连接体.
- 结构分析揭示了基于连接体结构的明显的超分子组合.
- (II) 复合物表现出有希望的细胞保护性质,突出了它们作为抗氧化剂的潜力.
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