精油和基于酒精的溶液对包裹病毒替代物的比较杀毒活性:在体外和在体内分析
Valentina Parra-Acevedo1, Raquel E Ocazionez1, Elena E Stashenko1
1Centro de Cromatografía y Espectrometría de Masas-CROM-MASS, Universidad Industrial de Santander, Bucaramanga 680002, Colombia.
Molecules (Basel, Switzerland)
|May 27, 2023
概括
精油表现出强大的抗病毒活性,为酒精消毒剂提供更安全的替代品. 这项研究表明,EO有效中和DENV-2和CHIKV,为环保的病毒消毒铺平了道路.
科学领域:
- 环境科学 环境科学
- 病毒学 病毒学
- 生物化学 生化学
背景情况:
- 基于酒精 (OH) 的消毒剂对人类健康和环境构成风险.
- 精油 (EOs) 是FDA普遍认可的安全 (GRAS) 和拥有抗病毒性质.
- 开发安全和环保的消毒剂是一个关键的公共卫生需求.
研究的目的:
- 评估精油 (EO) 作为消毒剂对包裹病毒的杀菌效果.
- 为了比较EO和酒精 (OH) 溶液对DENV-2和CHIKV的有效性.
- 为了研究EO化合物和病毒蛋白之间的分子相互作用.
主要方法:
- 定量悬浮试验以评估杀毒活性.
- 测试不同度的EO和OH溶液.
- 分子对接分析,以预测EO化合物与病毒蛋白的结合亲和力.
主要成果:
- 一个12%的EO+10%OH溶液在1分钟内实现了DENV-2和CHIKV的>4.0log10TCID50 (100%) 减少.
- 没有OH的12%的EO和3%的EO溶液分别在10分钟和30分钟后表现出显著的杀毒活性.
- 塞斯基特与病毒包膜蛋白 (DENV-2 E和CHIKV E1-E2-E3) 具有强烈的结合亲和关系.
结论:
- 精油显示出作为有效和安全的抗病毒消毒剂的巨大潜力.
- 电子消毒剂可以作为传统酒精消毒剂的环保替代品.
- 对基于EO的消毒剂进行进一步的研究对于公共卫生应用是有必要的.
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