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银纳米颗粒的生物合成和表征使用Tribulus terrestris种子:揭示了有前途的抗糖尿病潜力

Abdur Rahman¹, Gauhar Rehman¹, Nasrullah Shah²

¹Department of Zoology, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.

Molecules (Basel, Switzerland)

|May 27, 2023

概括

使用Tribulus terrestris种子的银纳米粒子 (AgNPs) 的绿色合成显示了糖尿病治疗的前景. 这些生物合成的AgNP有效地降低了小鼠的血糖水平,表明具有显著的抗糖尿病特性.

科学领域:

纳米技术纳米技术
绿色化学绿色化学
生物医学科学生物医学科学

背景情况:

绿色合成为纳米粒子生产提供了一种环保的方法.
银纳米粒子 (AgNPs) 正在探索各种治疗应用,包括糖尿病管理.

研究的目的:

使用 Tribulus terrestris 种子提取物生物合成银纳米粒子 (AgNPs).
为了描述合成的纳米粒子 (TT-AgNPs).
研究TT-AgNPs的体外和体外抗糖尿病潜力.

主要方法:

使用 Tribulus terrestris 种子提取物进行 AgNP 的生物合成.
使用FTIR,XRD,SEM和UV-Vis光谱进行表征.
在体外抗糖尿病试验 (葡萄糖吸收,葡萄糖吸附,α-氨基酶抑制).
在体内对链毒素诱导的糖尿病小鼠进行实验.

主要成果:

光谱分析证实了TT-AgNP的形成,具有380 nm的特征性表面等离子体共振.
SEM揭示了球形和均大小的纳米粒子.
在体外研究表明,显著的葡萄糖吸收 (78.45%) 和α-氨基酶抑制 (75.68%).
在体内研究表明,在接受TT-AgNPs治疗的糖尿病小鼠中,血糖水平显著降低.

结论:

Tribulus terrestris 种子提取物是AgNPs绿色合成的有效剂.
生物合成的TT-AgNP在体外和体外表现出相当大的抗糖尿病特性.
这些发现表明TT-AgNPs是治疗糖尿病的潜在治疗剂.

关键词:

这种植物是Tribulus terrestris.这是一种抗糖尿病药物.绿色合成是一种绿色合成.银色纳米颗粒的使用方法

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