缺乏症,孕产妇的低甲状腺血和影响胎儿大脑发育的内分泌干扰:一个范围审查
Rolf Grossklaus1, Klaus-Peter Liesenkötter2, Klaus Doubek3
1Department of Food Safety, Federal Institute for Risk Assessment, D-10589 Berlin, Germany.
Nutrients
|May 27, 2023
概括
怀孕期间轻度缺乏会损害胎儿大脑发育. 内分泌干扰剂可能会加剧这些影响,强调需要补充和减少对有害化学品的暴露.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 怀孕期间轻度至中度的缺乏症和孕产妇的甲状腺过低血症可能会对胎儿的大脑发育产生负面影响.
- 内分泌干扰化学物质 (EDC) 无处不在,对母亲的甲状腺激素系统构成额外的威胁.
- 缺乏和EDC暴露的综合影响可能会加剧后代的神经发育问题.
研究的目的:
- 批判性地审查过去30年来关于缺乏和内分泌干扰剂对胎儿大脑发育的影响的文献.
- 强调孕妇和生育年龄的妇女充足的供应的重要性.
- 突出缺乏和内分泌干扰剂带来的协同风险.
主要方法:
- 对过去30年的科学出版物的综合回顾.
- 对现有研究成果进行批判性讨论.
- 综合有关缺乏,母亲甲状腺功能,内分泌干扰物和神经发育结果的证据.
主要成果:
- 有足够的证据表明,怀孕期间的缺乏会影响胚胎/胎儿的大脑发育,导致潜在的认知和社会缺陷.
- 内分泌干扰剂可以加剧缺乏对胎儿神经发育的负面影响.
- 充足的摄入量对于健康的胎儿和新生儿发育至关重要,可以减轻内分泌干扰物的影响.
结论:
- 充足的供应对于所有处于生育年龄的妇女至关重要,以防止儿童出现不良的神经发育结果.
- 建议在有轻度至中度缺乏地区的妇女服用个人补充剂,特别是在普遍盐化不足的地方.
- 根据预防原则,需要采取紧急策略来识别和减少对内分泌干扰物的暴露.
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