胡卜素饮食:消化,肠道微生物群调节和炎症性疾病
Helena R Rocha1, Marta C Coelho1, Ana M Gomes1
1CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Nutrients
|May 27, 2023
概括
摄入富含胡卜素的水果和蔬菜可以降低慢性疾病的风险. 需要进一步研究胡卜素代谢及其对细胞通路的影响,以获得更好的健康结果.
科学领域:
- 营养科学 营养科学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 流行病学研究将水果和蔬菜摄入量与降低慢性疾病风险联系起来,包括癌症和心血管疾病 (CVD).
- 胡卜素,普遍存在的脂溶性植物化学物质,通过它们对细胞内信号和基因表达的影响,与这些健康益处有关.
- 胡卜素容易氧化和异构,影响其稳定性和生物可用性.
研究的目的:
- 审查目前对胡卜素生物活性及其在健康中的作用的理解.
- 确定有关胡卜素消化,稳定性和肠道微生物群相互作用的研究缺口.
- 突出需要进一步调查胡卜素代谢物及其对细胞过程的影响.
主要方法:
- 流行病学研究和关于胡卜素生物活性研究的文献综述.
- 分析有关胡卜素代谢,稳定性和信号通路的现有数据.
- 确定需要进一步科学研究的领域.
主要成果:
- 胡卜素会影响细胞内信号级联,影响基因表达和蛋白质翻译.
- 关于胡卜素的胃肠道输送,消化,稳定性和肠道微生物群调节,存在重大知识差距.
- 胡卜素在调节氧化应激和炎症途径中的作用需要更多的研究.
结论:
- 虽然胡卜素在疾病预防方面表现有前途,但它们的复杂相互作用和代谢途径需要进一步阐明.
- 未来的研究应该专注于胡卜素的关系,代谢物,以及它们对转录因子和代谢的确切影响.
- 了解这些方面对于利用胡卜素的全部健康潜力至关重要.
更多相关视频
08:53Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
874
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.3K
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
365
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
365
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:50What is Monogastric Digestion?
71.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.7K
01:17Chronic Bowel Disorders: Introduction
493
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
493
01:25Regulation of the Digestive System
715
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
The effectors in this regulation system are glands and smooth muscles. Activation of...
715
01:28Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K