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儿童中枢神经系统瘤幸存者的肥胖风险:一个横截面研究
Rebekah L Wilson1,2, Jacqueline Soja3, Alexandra G Yunker1,4
1Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Nutrients
|May 27, 2023
概括
儿童中枢神经系统 (CNS) 瘤的成年幸存者面临高风险. 这项研究确定了男性性别,年龄较大和脑瘤是这些幸存者的主要肥胖风险因素.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 儿童中枢神经系统 (CNS) 瘤的成年幸存者经历了显著的长期健康问题.
- 肥胖是一个越来越令人担忧的问题,影响了这个弱势群体的发病率和死亡率.
- 了解肥胖风险因素对于有效的幸存者护理至关重要.
研究的目的:
- 在流行病学上描述儿童中枢神经系统瘤的年轻成年幸存者.
- 用身体质量指数 (BMI) 来识别与肥胖相关的风险因素.
- 为改善长期健康结果提供有针对性的干预信息.
主要方法:
- 针对儿童中枢神经系统瘤治疗的年轻成年幸存者 (18-39岁) 的截面研究.
- 从医疗记录 (2016-2021) 中提取的数据,包括人口统计,BMI和诊断.
- 使用t测试,费舍尔精确测试和多变量逻辑回归的统计分析.
主要成果:
- 分析了198名幸存者:体重不足4.0%,健康体重40.9%,超重26.8%,肥胖20.2%,严重肥胖8.1%.
- 大多数幸存者超重或肥胖.
- 确定了显著的肥胖风险因素:男性性别 (OR 2.41),年龄较大 (OR 1.10) 和瘤诊断 (OR 5.76).
结论:
- 儿童中枢神经系统瘤幸存者有超重和肥胖的高患病率.
- 需要有针对性的查和干预措施来解决在幸存者护理中的肥胖问题.
- 未来的努力应该考虑超出BMI的精确身体成分测量.
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