根据食物组的基因多态和失眠风险之间的关联:KoGES纵向研究
1Department of Food and Nutrition, College of Health Science, Kangwon National University, Samcheok 25949, Republic of Korea.
Nutrients
|May 27, 2023
概括
饮食和CLOCK基因影响失眠风险. 果实,肉类和饮料等特定食物组与CLOCK基因变异相互作用,以减轻或加剧失眠风险,特别是在男性和女性中.
科学领域:
- 遗传学和循环生物学的日复一日.
- 营养流行病学 营养流行病学
- 睡眠医学 睡眠医学
背景情况:
- 时钟昼夜调节器 (CLOCK) 基因在调节昼夜节律方面发挥着至关重要的作用,这可以影响睡眠模式.
- 以前的研究表明,CLOCK基因与失眠风险之间存在联系,但饮食因素的影响仍未得到充分研究.
研究的目的:
- 研究CLOCK基因多态 (rs12649507和rs4580704) 与失眠风险之间的关联.
- 检查特定食物组对CLOCK基因变异和失眠之间的关系的相互作用影响.
- 为了确定这些相互作用是否在男性和女性之间有所不同.
主要方法:
- 一项涉及1430名成年人的纵向研究,在2005年至2012年期间发现了新的失眠病例.
- CLOCK基因单核酸多态 (SNP) rs12649507和rs4580704.4的基因定型
- 评估饮食摄入量和分析使用Cox比例危险模型来评估基因-饮食相互作用.
主要成果:
- 时钟rs12649507:在男性中,水果和肉类摄入减轻了失眠风险. 在女性中,饮料摄入加剧了失眠风险.
- 时钟rs4580704:在男性中,水果和肉类摄入量改变了失眠风险. 在女性中,饮料摄入加剧了失眠风险.
- 观察到显著的基因与饮食相互作用,男性和女性对特定食物组和CLOCK基因变异有明显的影响.
结论:
- 与CLOCK基因多态性相关的失眠风险因饮食摄入而显著改变.
- 水果和肉类的消费可能会对与男性的CLOCK变体相关的失眠产生保护作用.
- 饮料消费似乎增加了与女性的CLOCK变体相关的失眠风险.
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