通过亲氧化剂-抗氧化剂平衡改变的高血压和中风复发之间的关联:一个多中心研究
Thu T M Pham1,2, Tuyen Van Duong3, Lien T K Nguyen4,5,6
1School of Public Health, College of Public Health, Taipei Medical University, Taipei 110-31, Taiwan.
Nutrients
|May 27, 2023
概括
高血压会增加中风复发的风险,但平衡的亲氧化剂-抗氧化剂 (PAB) 状态可以减轻这种影响. 关注PAB的生活方式干预措施可能有助于预防中风.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 高血压和氧化应激是中风病理生理学的关键因素.
- 研究亲氧化剂-抗氧化剂平衡 (PAB) 在与高血压相关的中风复发 (SR) 中的作用至关重要.
研究的目的:
- 检查PAB如何改变高血压和中风复发之间的关联.
- 了解越南中风患者队列中高血压,PAB和SR的相互作用.
主要方法:
- 越南951名中风患者的横截面研究 (2019年12月至2020年12月).
- 通过药物或BP值 (≥140/90 mmHg) 定义的高血压.
- PAB的计算方法是使用对抗氧化能力 (吸烟,饮酒,肥胖) 和抗氧化能力 (饮食,体力活动) 的加权系数. 用于分析的多重逻辑回归.
主要成果:
- 高血压的流行率为72.8%,SR为17.5%.
- 高血压显著增加了SR的可能性 (OR=1.93,p=0.004).
- 较高的PAB得分与较低的SR可能性有关 (OR=0.87,p=0.003),PAB减轻了高血压的SR风险 (OR=0.83,p=0.022).
结论:
- 高血压对中风复发的有害影响可以通过有利的亲氧化剂-抗氧化剂平衡来减轻.
- 干预措施应强调影响PAB的健康行为,以有效的中风预防策略.
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