基因饮食对癌症的长期影响
Ryuichiro Egashira1, Michiko Matsunaga1,2, Akimitsu Miyake3
1Department of Advanced Hybrid Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Nutrients
|May 27, 2023
概括
性饮食可能会改善晚期癌症患者的生存率. 在后续研究中,较长时间坚持性饮食与明显更好的整体存活率相关.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 代谢医学是一种代谢医学.
背景情况:
- 素饮食被探索为支持性癌症治疗,但长期生存影响是有争议的.
- 之前的研究结果表明,在37/55名晚期癌症患者中,基因饮食3个月或更长时间的基因饮食带来了好处.
- 扩展后续数据对于验证这些初步观察结果至关重要.
研究的目的:
- 分析一种性饮食对晚期癌症患者整体生存期 (OS) 的长期影响.
- 评估基因饮食坚持时间和患者结果之间的关联.
- 提供关于性饮食作为补充癌症治疗的疗效的进一步证据.
主要方法:
- 对55名先进癌症患者的随访分析,这些患者最初在2013年至2018年期间被录取.
- 对坚持性饮食≥12个月的患者与<12个月的患者之间的结局进行比较.
- 应用治疗权重的逆概率和调整的日志等级测试用于统计分析.
主要成果:
- 在37名患者的小组中,中位数的生存寿命为25.1个月,五年生存率为23.9%.
- 坚持性饮食12个月以上 (n=21) 的患者的平均寿命 (55.1个月) 与坚持12个月以下 (n=32,平均寿命12个月) 的患者相比显著更长.
- 经过调整后的分析证实,更长的性饮食持续时间显著改善了OS率 (p < 0.001).
结论:
- 长期坚持性饮食与晚期癌症患者的预后改善有关.
- 这些发现支持了持续饮食作为瘤学支持疗法的潜在作用.
- 需要进一步的研究来阐明机制,并优化性饮食在癌症治疗中的应用.
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