性,营养和NAFLD:环境污染的相关性
Arianna Dolce1, Sara Della Torre1
1Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.
Nutrients
|May 27, 2023
概括
环境污染物可能导致全球非酒精性脂肪肝疾病 (NAFLD) 发病率上升. 暴露,特别是在怀孕期间,可以破坏后代的肝脏代谢和编程,影响NAFLD的发展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 环境健康 环境健康
- 内分泌学 在内分泌学.
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是一种普遍存在的慢性肝病,治疗方法有限.
- 它日益增长的全球流行并不能完全由生活方式,遗传学或表观遗传学单独解释.
- 作为内分泌干扰剂的环境污染物是潜在的贡献者.
研究的目的:
- 审查将环境污染物与NAFLD发病率联系在一起的证据.
- 突出污染物在代谢功能障碍中的作用,特别是在女性中.
- 为了强调子宫内暴露于内分泌干扰化学物质的影响.
主要方法:
- 对因果关系证据的文献综述.
- 分析污染物进入食物链的途径.
- 检查污染物,营养素和肝脏/生殖功能之间的相互作用.
主要成果:
- 环境污染物可以进入食物链,导致通过受污染的食物和水摄入.
- 污染物可能会破坏肝脏代谢和生殖功能,可能会改变NAFLD的性别差异.
- 孕期暴露于内分泌干扰化学物质可能会影响后代的肝脏代谢编程.
结论:
- 环境污染物是不断升级的NAFLD流行病的一个合理因素.
- 进一步的研究对于阐明污染物对NAFLD影响的机制和程度至关重要.
- 了解这些环境因素对于制定有效的NAFLD预防和治疗策略至关重要.
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