坚果消费对非酒精性脂肪性肝病的影响:系统性审查和元分析
Ling Pan1, Jing Sui1,2, Ying Xu1
1Research Institute for Environment and Health, Nanjing University of Information Science and Technology, Nanjing 210044, China.
Nutrients
|May 27, 2023
概括
这次元分析发现,较高的坚果消费显著降低了非酒精性脂肪肝疾病 (NAFLD) 的风险. 这些发现表明,坚果可以提供对NAFLD发展的保护性益处.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题,与复杂的饮食联系.
- 之前关于坚果消费和NAFLD风险的研究已经产生了不一致的结果,需要进一步调查.
研究的目的:
- 进行观察性研究的元分析.
- 评估关于坚果消费对NAFLD风险的影响的最新证据.
- 为了探索潜在的性别特异性影响.
主要方法:
- 在PubMed和Web of Science数据库中进行全面的文献搜索,截至2023年4月.
- 包括11项观察性研究 (2个队列,3个横截面,7个病例控制).
- 用于元分析的随机效应模型.
主要成果:
- 总坚果摄入量和NAFLD风险之间观察到显著的负相关性 (OR = 0.90;95% CI:0.81-0.99).
- 较高的坚果消费与NAFLD的几率降低有关.
- 亚组分析表明,女性的保护作用更强 (OR = 0.88;95% CI:0.78-0.98).
结论:
- 坚果消费显示出与非酒精性脂肪肝疾病发展风险的显著保护关系.
- 对饮食成分和NAFLD进行进一步的研究是有必要的,特别是探索特定的食品组及其影响.
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