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降低了2型先天性淋巴细胞细胞频率在专利"Wuchereria bancrofti" - 感染个体

Ruth S E Tamadaho¹, Jubin Osei-Mensah^2,3, Kathrin Arndts¹

¹Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), 53127 Bonn, Germany.

Pathogens (Basel, Switzerland)

|May 27, 2023

概括

淋巴状疹 (LF) 感染减少了特定的免疫细胞,但大规模药物管理 (MDA) 疗法恢复了免疫平衡. 这表明活跃的感染驱动免疫变化,而不是清除后的持久影响.

科学领域:

免疫学免疫学免疫学
寄生虫学的寄生虫学
传染性疾病传染性疾病

背景情况:

淋巴状病 (LF) 影响全球数百万人,主要是由Wuchereria bancrofti引起的.
大量药物管理 (MDA) 已经减少了LF的患病率,但其对宿主免疫力的影响尚不清楚.
了解LF的免疫反应对于疾病管理和根除工作至关重要.

研究的目的:

为了研究活跃的Wuchereria bancrofti感染,治愈的感染和对照个体的免疫细胞组成.
为了在不同的LF感染状态中比较髓质衍生抑制细胞 (MDSC),巨细胞子集和先天性淋巴细胞 (ILC).
通过MDA.通过感染清除后,确定LF诱导的免疫变化是否持续存在.

主要方法:

对免疫细胞种群的分析,包括MDSCs,M2巨细胞和ILC子集 (ILC1,ILC2,ILC3).
细胞频率的比较,在个人与专有的LF (CFA+ MF+),潜伏的LF (CFA+ MF-),先前感染 (PI),特有正常 (EN) 和淋巴 (LE).
利用了加纳西部地区的个体的样本.

主要成果:

在患有活跃W. bancrofti感染的个体中,先天性淋巴细胞2 (ILC2) 的频率显著降低.
在研究组中,MDSCs,M2巨细胞,ILC1和ILC3的频率仍然可比.
由MDA诱导的感染清除恢复了ILC2频率,表明可能向淋巴组织迁移.

结论:

减少的ILC2频率与活跃的Wuchereria bancrofti感染有关.
治愈个体的免疫细胞组成在很大程度上类似于未感染的对照.
Filarial 驱动的免疫变化需要活跃的感染,并且在清除后可逆.

关键词:

在M2巨细胞中.沃切里亚的银行被剥夺了治愈了感染的感染.filarial 特定的免疫反应.免疫调节的免疫调节天生的淋巴细胞 (ILCs)大规模的药物管理.骨髓系衍生抑制细胞 (MDSCs) 是一种

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