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在血液透析患者中感染E型肝炎病毒 (HEV):希腊东北部的多中心流行病学队列研究
Dionysios Kogias1, Aikaterini Skeva2, Andreas Smyrlis3
1First Department of Internal Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Pathogens (Basel, Switzerland)
|May 27, 2023
概括
在希腊的血液透析患者中,暴露于E型肝炎病毒 (HEV) 是常见的,其中10.4%的患者表现为血清阳性. 居住和与动物接触是这种脆弱人群中HEV感染的关键风险因素.
科学领域:
- * 传染病 传染病
- * 肝病学 肝病学是一门专业.
- * 流行病学 流行病学
背景情况:
- * 肝炎E病毒 (HEV) 是病毒性肝炎的重要原因,主要通过便-口腔传播.
- * 医院传染,特别是亲肠传染,是血液透析患者的担忧.
- *先前在希腊血液透析患者中进行的HEV血清流行研究产生了相互矛盾的结果.
研究的目的:
- * 确定希腊东北部血液透析患者中HEV暴露的血清流行率.
- * 为了确定与此队列中HEV感染相关的潜在风险因素.
- *评估血液透析患者常规HEV查的需要.
主要方法:
- *从希腊东北部6个中心的405名血液透析患者收集了血清样本.
- *使用敏感的酶相关免疫吸收试验 (ELISA) 检测出抗HEV IgG抗体.
- *使用嵌套RT-PCR测试了HEVRNA;分析了风险因素的关联.
主要成果:
- *总共有10.4% (42/405) 的患者检测出抗HEVIgG抗体.
- * 在任何测试样本中都没有检测到HEV RNA.
- *HEV血清阳性与居住地区和与猪或鹿接触有显著联系.
结论:
- * 在希腊的血液透析患者中,HEV血清发生率较高.
- * 农业职业和地理位置是HEV感染的独立风险因素.
- *建议对血液透析患者进行定期的HEV查,不论其持续时间或症状如何.
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