阴道液中的HTLV-1前病毒载荷与周围血液单核细胞中的水平相关
Alisson de Aquino Firmino1, Paulo Roberto Tavares Gomes Filho1, Adenilda Lima Lopes Martins1,2
1Integrative Multidisciplinary HTLV Center (CHTLV), Bahiana School of Medicine and Public Health (EBMSP), Salvador 40290-000, Bahia, Brazil.
Pathogens (Basel, Switzerland)
|May 27, 2023
概括
人类T-淋巴变性病毒1型 (HTLV-1) 预病毒载量在阴道液中可检测,与血液水平相关. 这表明女性向男性的性传播和潜在的垂直传播.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 妇科 妇科 妇科 妇科
背景情况:
- 人类T-淋巴变性病毒1型 (HTLV-1) 感染在女性中更为普遍.
- 性交是HTLV-1从男性传播到女性的关键途径.
- 这项研究调查了阴道液中的HTLV-1前病毒载量 (PVL) 以及它与血液PVL的相关性.
研究的目的:
- 在阴道液中量化HTLV-1前病毒载量 (PVL).
- 评估阴道液PVL和周围血液单核细胞 (PBMC) PVL之间的相关性.
- 评估HTLV-1感染妇女的细胞病理变化和阴道微生物群.
主要方法:
- 在巴西萨尔瓦多招募感染HTLV-1的妇女.
- 通过妇科检查和静脉穿刺收集宫性阴道液和血液样本.
- 使用RT-qPCR对HTLV-1PVL的量化和通过光显微镜对细胞病理和微生物群的评估.
主要成果:
- 在PBMC中,HTLV-1PVL显著高于阴道液 (p < 0.0001).
- 在PBMC中的PVL和阴道液之间发现了直接的相关性 (R = 0.37,p = 0.006).
- 在HAM/TSP患者 (92.3%) 和无症状携带者 (55.8%) 相比,阴道液中PVL检测率更高.
结论:
- 在阴道分泌物中可以检测到HTLV-1前病毒载量.
- 阴道和血液PVL之间的直接相关性支持从女性向男性的性传播.
- 研究结果表明,垂直传播的可能性很大,尤其是在阴道分娩期间.
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