型肝炎和血病:一个故事 (几乎) 有着快乐的结局
1Ospedale Pediatrico Microcitemico, Via Jenner Sn, 09121 Cagliari, Italy.
Pathogens (Basel, Switzerland)
|May 27, 2023
概括
型肝炎病毒 (HCV) 治疗对血病患者有效,但长期肝损伤和癌症风险仍然存在. 在一些地区,未经查的献血仍然在全球范围内构成重大感染风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 输血医学 输血医学
- 在瘤学瘤学.
背景情况:
- 在发达国家,肝炎C病毒 (HCV) 输血后的传播在很大程度上受到控制.
- 直接抗病毒药物有效地治疗HCV在大多数血病患者.
- 慢性HCV感染导致长期肝损伤 (纤维化) 和癌症风险,即使在病毒清除后.
研究的目的:
- 为了突出HCV感染在血病患者的持续风险,尽管治疗进展.
- 为了强调全球血病患者中HCV的持续流行情况.
- 为了应对衰老的乳腺癌患者的肝细胞癌风险增加,这些患者有HCV病史.
主要方法:
- 关于HCV治疗和血病的结果的当前文献的审查.
- 对血病患者中HCV患病率的流行病学数据的分析.
- 检查长期后果,包括肝纤维化和肝细胞癌风险.
主要成果:
- 虽然HCV是可以治疗的,但长期的肝脏和肝脏外的后果仍然存在.
- 肝细胞癌的风险是显著高于 Thalassemia 患者之前的 HCV,特别是那些肝硬化.
- 在资源有限的环境中,不充分的血液查 (高达25%) 导致了血病患者的持续高HCV患病率.
结论:
- thalassemia患者面临过去HCV感染的持久风险,包括肝病和癌症.
- 血液查实践的全球差异使脆弱人群中HCV的流行率保持不变.
- 持续的监测和管理对于减轻与高血有关的长期健康问题至关重要.
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