阿里利米达米德具有针对血液传播的查加斯病的化学预防的潜力
Bruno Lisboa Timm1, Aline Nefertiti Silva da Gama1, Marcos Meuser Batista1
1Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil.
Pathogens (Basel, Switzerland)
|May 27, 2023
概括
阿里利米达胺 (AIAs) 显示出对血液样本的灭菌有希望,这些血液样本被Trypanosoma cruzi污染,这是导致查加斯病 (CD) 的寄生虫. 一种AIA化合物在输血安全研究中显著改善了动物的生存率.
科学领域:
- 寄生虫学的寄生虫学
- 血液学 血液学 血液学
- 药物发现 药物发现 药物发现
背景情况:
- 查加斯病 (CD) 构成一个重大的全球健康风险,而阳性转移是令人担忧的.
- 水晶紫 (CV),过去的病原体减少剂,有有害的副作用.
- 开发安全有效的血液病原体减少方法对于输血安全至关重要.
研究的目的:
- 评估阿里利米达米德 (AIAs) 作为潜在的杀菌剂的疗效和安全性,用于杀菌被Trypanosoma cruzi.污染的血液样本.
- 为了比较AIAs与Crystal Violet (CV) 在小鼠血液中减少Trypanosoma cruzi寄生病的疗效.
主要方法:
- 实验性污染的小鼠血液样本与Trypanosoma cruzi血流皮虫 (BT).
- 用三个AIA和CV处理的血液样本在非溶血剂量.
- 评估了对小鼠血液细胞的毒性和心脏细胞培养中的体外感染.
- 进行体内测试以评估寄生虫抑制和动物生存率.
主要成果:
- AIAs对小鼠血细胞的毒性没有被证明是高达96μM的.
- 用AIAs进行预治疗损害了Trypanosoma cruzi感染在心脏细胞培养物中的建立.
- 在体内,AIA和CV (96μM) 显著抑制了寄生虫病峰值.
- AIA DB1831实现了90%以上的动物存活率,而用车辆处理的对照组的存活率为0%.
结论:
- 阿里利米达米德显示出作为Trypanosoma cruzi病原体减少血液中的安全和有效药物的潜力.
- 根据AIA DB1831,需要进一步调查血液库的应用程序,以防止查加斯病的传播.
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