移植接受者患有密码球菌脑膜炎的陷综合征
Laya Reddy1, George R Thompson1,2, Alan Koff1
1Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Pathogens (Basel, Switzerland)
|May 27, 2023
概括
陷入角综合征 (ETH) 是Cryptococcus neoformans感染的罕见中枢神经系统 (CNS) 并发症. 这一案例突出显示了移植接受者的ETH,这种表现在这个人群中以前没有记录过.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 移植医学 移植医学 移植医学
背景情况:
- 新型是一种真菌病原体,经常导致中枢神经系统 (CNS) 感染,特别是在免疫受损的个体中.
- 陷入角综合征 (ETH) 是中枢神经系统密码球菌病的罕见表现,其特点是特定的成像发现.
- 固体器官移植接受者有机会性感染的风险增加,包括加密球菌病.
研究的目的:
- 报告一个罕见的陷入角综合征 (ETH) 在一个固体器官移植接收者的病例.
- 描述这种独特的中枢神经系统并发症的临床表现和管理.
- 提高人们对ETH的认识,认为ETH是移植患者患有密码菌病的潜在神经学并发症.
主要方法:
- 案例报告的呈现方式.
- 对临床病史,诊断成像和治疗过程的审查.
- 对类似案件的文献审查.
主要成果:
- 一名55岁的女性移植接受者在经过治疗的Cryptococcal脑膜炎后发展了ETH.
- 患者的临床过程和成像发现与ETH一致.
- 这代表了第一个报告的ETH在固体器官移植接受者的实例.
结论:
- 陷入角综合征 (ETH) 可能发生在有Cryptococcus neoformans中枢神经系统感染史的固体器官移植受体中.
- 这一案例扩大了已知的中枢神经系统表现的加密球菌病的范围.
- 临床医生应在免疫功能低下患者,特别是移植受体的神经症状的差异诊断中考虑ETH.
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